HPV vaccine lasts for four years Updated: Monday, November 4, 2013 | (NEWSCHANNEL 3) - Just one dose of the HPV vaccine may provide women protection against the virus that causes cervical cancer.Researchers studied women from Costa Rica and found those who were vaccinated with one dose had antibodies against the human papillomavirus for up to four years."We're always trying to provide the most protection with the fewest inoculations but at the moment the three dose series is the standard and that is what we ought to maintain until we get data telling us otherwise," said Dr. William Schaffner of the Vanderbilt Medical Center. In the U.S., just 58 percent of girls between 13 and 17 years old have received the first dose of the HPV vaccine. Health officials had recommended three doses of the vaccine. About a third of girls get all three shots.